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apalutamide will lower the level or impact of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with medications which have been CYP3A4 substrates can lead to reduce exposure to these medications.Young adults and children youthful than 17 de